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Lithium Hexamethyldisilazide (LHS) 24% in THF

LHS is a non-pyrophoric strong base, widely employed in organic synthesis as a metalation agent. The principle advantages of this reagent are the improved selectivity obtained in deprotonation reactions and the enhanced thermal stability. It is employed as a base in generating enolates for the preparation of lactone precursors. (1) J.Org. Chem. 1993, 58, 7304. (2) Synlett 1993, 507. (3) Tetrahedron 1994, 50, 9061. LHS is offered as a THF solution, and is therefore simple to transfer from the shipping container to a reactor or storage vessel. LHS is a more stable base than lithium diisopropylamide (LDA).

CAS #: 4039-32-1

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